In many industrial manufacturing companies, energy has become a major cost factor. Energy aspects are included in the decision-making system of production line planning and control to reduce manufacturing costs. For this priority, the simulation of production line processes requires not only the consideration of logistical and technical production factors but also the integration of time-dependent energy flows. A hybrid (multimethod) simulation shows the complex interactions between material flow and energy usage in production close to reality. This paper presents a simulation approach combining System Dynamics, Discrete-Event and Agent-Based Simulation for energy efficiency analysis in production, considering the energy consumption in the context of planning and scheduling operations.